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Chronic Inflammation Linked to Metabolic and Heart Disease Chronic inflammation creates a domino effect: It stiffens arteries, triggering high blood pressure and a greater risk of heart attacks and strokes. Cells become more resistant to insulin, making diabetes more likely and harder to control

Tirzepatide works on GLP-1 and GIP hormones, which control appetite and blood sugar

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Key genetic variants in the GLP1R gene (such as rs6923761), GIPR gene (rs1800437), FTO (rs9939609), and MC4R (rs17782313) regulate appetite signaling, energy expenditure, and fat storage capacity

However, they do affect dose accuracy because air displaces solution